Neuropsychiatric Traits Associated with Refractory Impulse Control Disorder in Parkinson's Disease
- Authors
- Choi, Ji-Hyun; Lee, Jee-Young; Jeon, Beomseok; Koh, Seong-Beom; Yoon, Won Tae; Lee, Ho-Won; Kwon, Oh Dae; Kim, Jae Woo; Kim, Jong-Min; Ma, Hyeo-Il; Kim, Hee Tae; Baik, Jong Sam; Cho, Jin Whan
- Issue Date
- 6월-2020
- Publisher
- KARGER
- Keywords
- Impulse control disorder; Parkinson' s disease; Dopamine agonist; Neuropsychiatric traits; Obsessive compulsiveness
- Citation
- NEURODEGENERATIVE DISEASES, v.19, no.5-6, pp.171 - 177
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEURODEGENERATIVE DISEASES
- Volume
- 19
- Number
- 5-6
- Start Page
- 171
- End Page
- 177
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/55470
- DOI
- 10.1159/000507447
- ISSN
- 1660-2854
- Abstract
- Introduction:Impulse control disorder (ICD) in Parkinson's disease (PD) is a critical nonmotor symptom with personality or neuropsychiatric traits contributing to ICD.Objective:This study aimed to identify predictive traits for persistent or paradoxical aggravation of ICD after dopamine agonist substitution therapy for ICD in PD.Methods:We conducted a case-control study using a database of a multicenter intervention trial for ICD in PD. The poor-outcome group was defined by showing paradoxical increases in ICD behaviors after the substitution of dopamine agonists with levodopa. We analyzed the pre-intervention personality traits associated with the poor outcome and also evaluated the risk traits for refractory ICD using a receiver-operating characteristic (ROC) curve analysis.Results:The poor-outcome group showed higher levels of anger expression (p =0.007) and obsessive-compulsive traits (p =0.009) compared with the good-outcome group at the pre-intervention state. In the ROC curve analysis, the Obsessive-Compulsive Inventory showed the highest area under the curve with 80.0% sensitivity and 74.3% specificity in discriminating against the poor-outcome group.Conclusions:Our results suggest that assessment of obsessive compulsiveness may be useful for predicting the refractoriness of ICD behaviors in planning an interventional treatment for ICD in PD.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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