Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
The Roles of CCR7 for the Homing of Memory CD8+T Cells into Their Survival Niches
- Authors
- Choi, Hanbyeui; Song, Heonju; Jung, Yong Woo
- Issue Date
- Jun-2020
- Publisher
- KOREA ASSOC IMMUNOLOGISTS
- Keywords
- CD8-positive T-lymphocytes; Immunologic memory; Receptors; CCR7; Cell movement; Chemotaxis; Immunotherapy
- Citation
- IMMUNE NETWORK, v.20, no.3
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- IMMUNE NETWORK
- Volume
- 20
- Number
- 3
- ISSN
- 1598-2629
- Abstract
- Memory CD8+ T cells in the immune system are responsible for the removal of external Ags for a long period of time to protect against re-infection. Naive to memory CD8+ T cell differentiation and memory CD8+ T cell maintenance require many different factors including local environmental factors. Thus, it has been suggested that the migration of memory CD8+ T cells into specific microenvironments alters their longevity and functions. In this review, we have summarized the subsets of memory CD8+ T cells based on their migratory capacities and described the niche hypothesis for their survival. In addition, the basic roles of CCR7 in conjunction with the migration of memory CD8+ T cells and recent understandings of their survival niches have been introduced. Finally, the applications of altering CCR7 signaling have been discussed.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Jung, Yong Woo
- College of Pharmacy (Department of Pharmaceutical Science)