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The Roles of CCR7 for the Homing of Memory CD8+T Cells into Their Survival Niches

Authors
Choi, HanbyeuiSong, HeonjuJung, Yong Woo
Issue Date
6월-2020
Publisher
KOREA ASSOC IMMUNOLOGISTS
Keywords
CD8-positive T-lymphocytes; Immunologic memory; Receptors; CCR7; Cell movement; Chemotaxis; Immunotherapy
Citation
IMMUNE NETWORK, v.20, no.3
Indexed
SCIE
SCOPUS
KCI
Journal Title
IMMUNE NETWORK
Volume
20
Number
3
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/55565
DOI
10.4110/in.2020.20.e20
ISSN
1598-2629
Abstract
Memory CD8+ T cells in the immune system are responsible for the removal of external Ags for a long period of time to protect against re-infection. Naive to memory CD8+ T cell differentiation and memory CD8+ T cell maintenance require many different factors including local environmental factors. Thus, it has been suggested that the migration of memory CD8+ T cells into specific microenvironments alters their longevity and functions. In this review, we have summarized the subsets of memory CD8+ T cells based on their migratory capacities and described the niche hypothesis for their survival. In addition, the basic roles of CCR7 in conjunction with the migration of memory CD8+ T cells and recent understandings of their survival niches have been introduced. Finally, the applications of altering CCR7 signaling have been discussed.
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