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Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo
- Authors
- An, Lijun; Ma, Jun; Yang, Xueyuan; Liang, Yue; Wang, Huimei; Tuerhong, Muhetaer; Lall, Namrita; Abudukeremu, Munira; Zhang, Yi; Lee, Dongho; Xu, Jing; Wu, Xiaohui; Guo, Yuanqiang
- Issue Date
- 5월-2020
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Homotriterpenoid; Anti-inflammation; Zebrafish model; Molecular docking; Casearia kurzii
- Citation
- BIOORGANIC CHEMISTRY, v.98
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC CHEMISTRY
- Volume
- 98
- ISSN
- 0045-2068
- Abstract
- Caseahomopene A (1), a rare natural product with a ring-expanded homotriterpenoid skeleton, was isolated from the leaves of Casearia kurzii. The structure including the absolute configuration was determined by spectroscopic data and X-ray crystallography analysis. Compound 1 showed anti-inflammatory effects in vitro and in vivo using LPS-stimulated cell and zebrafish model. As a potential anti-inflammatory agent, the anti-inflammatory mechanism of 1 was also investigated.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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