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Methylglyoxal-derived advanced glycation end products induce matrix metalloproteinases through activation of ERK/JNK/NF-kappa B pathway in kidney proximal epithelial cells

Authors
Jeong, So-RaPark, Ho-YoungKim, YoonsookLee, Kwang-Won
Issue Date
5월-2020
Publisher
KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
Keywords
Advanced glycation end products; Diabetic nephropathy; Matrix metalloproteinase; MAPK; NF-kappa B
Citation
FOOD SCIENCE AND BIOTECHNOLOGY, v.29, no.5, pp.675 - 682
Indexed
SCIE
SCOPUS
KCI
Journal Title
FOOD SCIENCE AND BIOTECHNOLOGY
Volume
29
Number
5
Start Page
675
End Page
682
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/56209
DOI
10.1007/s10068-019-00704-7
ISSN
1226-7708
Abstract
The accumulation of reactive alpha-dicarbonyl leading to advanced glycation end products (AGEs) have been linked to pathophysiological diseases in many studies, such as atherosclerosis, cataract, cancer, and diabetic nephropathy. Glycation-generated AGEs increase the expression of inflammatory cytokines by transferring signals to the cell by binding them to the receptor for AGEs (RAGE) on their cell surface. The effect of methylglyoxal-derived AGEs (AGE-4) on the induction of matrix metalloproteinases (MMPs) in rat ordinary kidney cells (NRK-52E) was explored in this research, among other AGEs. The cell treated with 100 mu g/mL AGE-4 for 24 h showed a substantial rise in MMP-2 and MMP-9 expression relative to BSA control only and other AGEs through ERK, JNK, and NF-B pathways. Our findings therefore suggest that AGE-4 expresses MMPs through the AGE-4-RAGE axis, activating MAPK signals that may contribute to dysfunction of the kidney cell.
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