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Clerodane Diterpenoids Isolated from the Leaves of Casearia graveolens
- Authors
- Liu, Feng; Ma, Jun; Shi, Zhaoyu; Zhang, Qi; Wang, Huimei; Li, Dihua; Song, Zhaohui; Wang, Chunyan; Jin, Jin; Xu, Jing; Tuerhong, Muhetaer; Abudukeremu, Munira; Shuai, Ling; Lee, Dongho; Guo, Yuanqiang
- Issue Date
- Jan-2020
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.83, no.1, pp.36 - 44
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 83
- Number
- 1
- Start Page
- 36
- End Page
- 44
- ISSN
- 0163-3864
- Abstract
- A phytochemical survey aiming to acquire pharmacologically active substances has resulted in the isolation of nine new clerodane diterpenoids, named graveospenes A-I (1-9), from the leaves of Casearia graveolens. Spectroscopic methods were employed to establish the structures with their absolute configurations being confirmed by ECD data analysis. A biological evaluation was performed, and compound 1 was found to be cytotoxic to both human lung cancer cells (A549) and human hepatocellular carcinoma cells (HepG2). A mechanism-of-action study on 1 revealed this compound to induce apoptosis of A549 cells and impede them at the G(0)/G(1) stage.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology