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Origami-paper-based device for microvesicle/exosome preconcentration and isolation
- Authors
- Kim, Hyerin; Lee, Kyu Hyoung; Han, Sung Il; Lee, Dongho; Chung, Seok; Lee, Dohwan; Lee, Jeong Hoon
- Issue Date
- 7-12월-2019
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- LAB ON A CHIP, v.19, no.23, pp.3917 - 3921
- Indexed
- SCIE
SCOPUS
- Journal Title
- LAB ON A CHIP
- Volume
- 19
- Number
- 23
- Start Page
- 3917
- End Page
- 3921
- ISSN
- 1473-0197
- Abstract
- Microvesicles and exosomes are promising liquid biopsy biomarkers. However, conventional isolation techniques damage and contaminate the biomarkers. We developed an origami-paper-based device for effective isolation of biomarkers with less damage and in fewer steps. The multi-folded device enables the preconcentration of the microvesicles/exosomes on specific layers (similar to 5-fold) by the ion concentration polarization technique and they were simply isolated from the rest of the sample by unfolding the device.
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Collections - College of Engineering > Department of Mechanical Engineering > 1. Journal Articles
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