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Autoimmunity in microbiome-mediated diseases and novel therapeutic approaches

Authors
Shin, CheolminKim, Yong-Ku
Issue Date
12월-2019
Publisher
ELSEVIER SCI LTD
Citation
CURRENT OPINION IN PHARMACOLOGY, v.49, pp.34 - 42
Indexed
SCIE
SCOPUS
Journal Title
CURRENT OPINION IN PHARMACOLOGY
Volume
49
Start Page
34
End Page
42
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/61370
DOI
10.1016/j.coph.2019.04.018
ISSN
1471-4892
Abstract
The microbiome mediates constant bidirectional communication with the host immune system in a delicate balance of inducing pathogenic infection or residing in the human body in a cornmensal state. Dysbiosis is a hallmark of several autoimmune and immune-mediated inflammatory diseases. Various pathways involved in microbiome-induced autoimmunity are activated when a genetic defect or microbial trigger is found in the inflammasome, neutrophil extracellular trap, or receptors for microbial sensitization in the innate immune system or when similar defects are present in T or B lymphocytes of the adaptive immune system. Regulating autoimmunity through microbiome modulation may be highly effective as a therapeutic intervention.
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