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NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum
- Authors
- An, Lijun; Liang, Yue; Yang, Xueyuan; Wang, Huimei; Zhang, Jie; Tuerhong, Muhetaer; Li, Dihua; Wang, Chunyan; Lee, Dongho; Xu, Jing; Shuai, Ling; Jin, Jin; Guo, Yuanqiang
- Issue Date
- 11월-2019
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- NO inhibitory effects; Euphorbia antiquorum; Diterpenoids; Inflammation; Molecular docking
- Citation
- BIOORGANIC CHEMISTRY, v.92
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC CHEMISTRY
- Volume
- 92
- ISSN
- 0045-2068
- Abstract
- Two new ent-atisane-type diterpenoids (1 and 2), three new lathyrane-type diterpenoids (3-5), and seven known analogues (6-12) were isolated from Euphorbia antiquorum. The structures of these diterpenoids were established by analysis of their NMR, MS, and electronic circular dichroism data. The anti-inflammatory activities were evaluated biologically and compounds 1, 4, 7, 8, and 10 displayed strong NO inhibitory effects with IC50, values less than 40 mu M. The potential anti-inflammatory mechanism was also investigated using molecular docking and Western blotting.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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