Short-term effects of anti-vascular endothelial growth factor on peripapillary choroid and choriocapillaris in eyes with neovascular age-related macular degeneration
- Authors
- Lee, Boram; Yoo, Gyeongmin; Yun, Cheolmin; Oh, Jaeryung
- Issue Date
- 10월-2019
- Publisher
- SPRINGER
- Keywords
- Optical coherence tomography angiography; Peripapillary choriocapillaris; Peripapillary choroidal thickness; Age-related macular degeneration
- Citation
- GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, v.257, no.10, pp.2163 - 2172
- Indexed
- SCIE
SCOPUS
- Journal Title
- GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
- Volume
- 257
- Number
- 10
- Start Page
- 2163
- End Page
- 2172
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/62666
- DOI
- 10.1007/s00417-019-04432-w
- ISSN
- 0721-832X
- Abstract
- Purpose To investigate the effects of anti-vascular endothelial growth factor (anti-VEGF) on the peripapillary choroid and choriocapillaris in eyes with neovascular age-related macular degeneration (nAMD). Methods We included consecutive patients who underwent three monthly intravitreal injections of aflibercept or ranibizumab for nAMD, followed by swept-source optical-coherence tomography angiography (SS-OCTA). Peripapillary choroidal thickness (CT) and vascular density (VD) of the peripapillary choriocapillaris were measured in SS-OCT and OCTA images at baseline and at 1 month after three monthly injections of anti-VEGF. Results In 68 eyes of 68 patients with nAMD, peripapillary CT decreased from 124.5 +/- 69.9 mu m to 116.5 +/- 68.2 mu m (P = 0.003) after three monthly intravitreal injections of anti-VEGF. The mean vascular density (VD) of the peripapillary choriocapillaris also decreased from 73.99 +/- 6.33 to 71.82 +/- 6.51 (P < 0.001). The change in the peripapillary choriocapillaris VD was significantly affected by baseline peripapillary choriocapillaris VD, baseline peripapillary CT, and type of nAMD (P = 0.004, P = 0.028, P = 0.015, respectively). The baseline VD of the choriocapillaris was lower in non-responders (median, 70.63; 25-75%, 68.12-71.27) than in responders (median, 75.32; 25-75%, 70.09-79.96) (P = 0.032). Conclusion These results suggest that anti-VEGF injection influences the peripapillary choriocapillaris flow out of exudative lesions, and that its effects depend on the baseline status of the choroid and choriocapillaris.
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