Clinical Value of Whole Blood Procalcitonin Using Point of Care Testing, Quick Sequential Organ Failure Assessment Score, C-Reactive Protein and Lactate in Emergency Department Patients with Suspected Infection
- Authors
- Shim, Bo-Sun; Yoon, Young-Hoon; Kim, Jung-Youn; Cho, Young-Duck; Park, Sung-Jun; Lee, Eu-Sun; Choi, Sung-Hyuk
- Issue Date
- 6월-2019
- Publisher
- MDPI
- Keywords
- procalcitonin; point-of-care testing; bacteremia; mortality
- Citation
- JOURNAL OF CLINICAL MEDICINE, v.8, no.6
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CLINICAL MEDICINE
- Volume
- 8
- Number
- 6
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/65257
- DOI
- 10.3390/jcm8060833
- ISSN
- 2077-0383
- Abstract
- We investigated the clinical value of whole blood procalcitonin using point of care testing, quick sequential organ failure assessment score, C-reactive protein and lactate in emergency department patients with suspected infection and assessed the accuracy of the whole blood procalcitonin test by point-of-care testing. Participants were randomly selected from emergency department patients who complained of a febrile sense, had suspected infection and underwent serum procalcitonin testing. Whole blood procalcitonin levels by point-of-care testing were compared with serum procalcitonin test results from the laboratory. Participants were divided into two groups-those with bacteremia and those without bacteremia. Sensitivity, specificity, positive predictive value, negative predictive value of procalcitonin, lactate and Quick Sepsis-related Organ Failure Assessment scores were investigated in each group. Area under receiving operating curve of C-reactive protein, lactate and procalcitonin for predicting bacteremia and 28-day mortality were also evaluated. Whole blood procalcitonin had an excellent correlation with serum procalcitonin. The negative predictive value of procalcitonin and lactate was over 90%. Area under receiving operating curve results proved whole blood procalcitonin to be fair in predicting bacteremia or 28-day mortality. In the emergency department, point-of-care testing of whole blood procalcitonin is as accurate as laboratory testing. Moreover, procalcitonin is a complementing test together with lactate for predicting 28-days mortality and bacteremia for patients with suspected infection.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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