Effectiveness of a Fractionated Therapy Scheme in Tumor Treating Fields Therapy
- Authors
- Jo, Yunhui; Sung, Jiwon; Jeong, Hyesun; Hong, Sunghoi; Jeong, Youn Kyoung; Kim, Eun Ho; Yoon, Myonggeun
- Issue Date
- 9-5월-2019
- Publisher
- SAGE PUBLICATIONS INC
- Keywords
- tumor treating fields; fractionated scheme; radiotherapy; glioblastoma; head and neck cancer
- Citation
- TECHNOLOGY IN CANCER RESEARCH & TREATMENT, v.18
- Indexed
- SCIE
SCOPUS
- Journal Title
- TECHNOLOGY IN CANCER RESEARCH & TREATMENT
- Volume
- 18
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/65433
- DOI
- 10.1177/1533033819845008
- ISSN
- 1533-0346
- Abstract
- This study aimed to evaluate the biological effectiveness of cancer therapy with tumor treating fields using a fractionated treatment scheme that was originally designed for radiotherapy. Discontinuous fractional tumor treating fields of an intensity of 0.9 to 1.2 V/cm and a frequency of 150 KHz were applied to U373 cancer cells and IEC6 normal cells for 3 days, with durations of 3, 6, 12, or 24 h/d. As the treatment duration of the tumor treating fields increased from 3 to 24 h/d, the relative tumor cell (U373) number (% of control) reduced in proportion to the treatment duration. Compared to a 25% cell number reduction (75% of control) for the group of 6 h/d treatment at 1.2 V/cm, only 5% (70% of control) and 8% (67% of control) of additional reductions were observed for the group of 12 and 24 h/d treatment, respectively. This experimental result indicates that the dependence on treatment duration in tumor cell inhibition was weakened distinctly at treatment duration over 6 h/d. For normal cells (IEC6), the relative cell number corresponding to the treatment time of the tumor treating fields at 1.2 V/cm of electric field strength was not decreased much for the treatment times of 3, 6, and 12 h/d, revealing 93.3%, 90.0%, and 89.3% relative cell numbers, respectively, but it suddenly decreased to similar to 73% for the 24 h/d treatment. Our results showed that the effects of tumor treating fields on tumor cells were higher than on normal cells for treatment duration of 3 to 12 h/d, but the difference became minimal for treatment duration of 24 h/d. The fractionated scheme, using tumor treating fields, reduced the treatment time while maintaining efficacy, suggesting that this method may be clinically applicable for cancer treatment.
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
- College of Health Sciences > School of Biomedical Engineering > 1. Journal Articles
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