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Prophylactic use of probiotic chocolate modulates intestinal physiological functions in constipated rats

Authors
Lee, Chul SangTan, Pei LeiEor, Ju YoungChoi, Da HyePark, MiriSeo, Sung KeumYoon, SeokminYang, SiyoungKim, Sae Hun
Issue Date
4월-2019
Publisher
WILEY
Keywords
constipation; functional chocolate; gastrointestinal function; intestinal barrier function; lactic acid bacteria
Citation
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, v.99, no.6, pp.3045 - 3056
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
Volume
99
Number
6
Start Page
3045
End Page
3056
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/66427
DOI
10.1002/jsfa.9518
ISSN
0022-5142
Abstract
BACKGROUND This study investigated the in vivo prophylactic effect of probiotic chocolate on constipation. Rats were administered chocolate containing 2.5 x 10(10) CFU g(-1) of probiotics daily for 4 weeks and treated with loperamide (5 mg kg(-1)) daily at the fourth week of treatment. RESULTS Probiotic chocolate treatment significantly (P < 0.05) increased the intestinal motility, colon length, fecal moisture content and number of excreted fecal pellets in constipated rats. Moreover, quantitative real-time polymerase chain reaction data and histological images also revealed that both probiotic chocolate LYC and BB12 treatments were capable of upregulating the mRNA expression levels of colonic ZO-1, occludin and AQP8, leading to the maintenance of the defensive barrier function in the constipated rats compared with the negative controls. Interestingly, these treatments also modulated gut bacterial populations by increasing the abundance levels of Lactobacillus and Bifidobacterium, as well as reducing the abundance level of Enterobacteriaceae. CONCLUSION The present study demonstrated that probiotic chocolate LYC and BB12 could potentially be used as alternative agents for prophylactic constipation. (c) 2018 Society of Chemical Industry
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