Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Ameliorative effect of black ginseng extract against oxidative stress-induced cellular damages in mouse hepatocytes

Authors
Choudhry, Qaisra NaheedKim, Jun HoCho, Hyung TaekHeo, WanLee, Jeong-JunLee, Jin HyupKim, Young Jun
Issue Date
4월-2019
Publisher
KOREAN SOC GINSENG
Keywords
antioxidant; black ginseng; chemoprotection; oxidative stress; Panax ginseng
Citation
JOURNAL OF GINSENG RESEARCH, v.43, no.2, pp.179 - 185
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF GINSENG RESEARCH
Volume
43
Number
2
Start Page
179
End Page
185
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/66441
DOI
10.1016/j.jgr.2017.10.003
ISSN
1226-8453
Abstract
Background: Oxidative stress induces the production of reactive oxygen species (ROS), which play important causative roles in various pathological conditions. Black ginseng (BG), a type of steam-processed ginseng, has drawn significant attention due to its biological activity, and is more potent than white ginseng (WG) or red ginseng (RG). Methods: We evaluated the protective effects of BG extract (BGE) against oxidative stress-induced cellular damage, in comparison with WG extract (WGE) and RG extract (RGE) in a cell culture model. Ethanolic extracts of WG, RG, and BG were used to evaluate ginsenoside profiles, total polyphenols, flavonoid contents, and antioxidant activity. Using AML-12 cells treated with H2O2, the protective effects of WGE, RGE, and BGE on cellular redox status, DNA, protein, lipid damage, and apoptosis levels were investigated. Results: BGE exhibited significantly enhanced antioxidant potential, as well as total flavonoid and polyphenol contents. ATP levels were significantly higher in BGE-treated cells than in control; ROS generation and glutathione disulfide levels were lower but glutathione (GSH) and NADPH levels were higher in BGE-treated cells than in other groups. Pretreatment with BGE inhibited apoptosis and therefore protected cells from oxidative stress-induced cellular damage, probably through ROS scavenging. Conclusion: Collectively, our results demonstrate that BGE protects AML-12 cells from oxidative stress-induced cellular damages more effectively than WGE or RGE, through ROS scavenging, maintenance of redox status, and activation of the antioxidant defense system. (C) 2017 The Korean Society of Ginseng, Published by Elsevier Korea LLC.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Food and Biotechnology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Young Jun photo

Kim, Young Jun
식품생명공학과
Read more

Altmetrics

Total Views & Downloads

BROWSE