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Protective effects of chebulic acid from Terminalia chebula Retz. against t-BHP-induced oxidative stress by modulations of Nrf2 and its related enzymes in HepG2 cells

Authors
Jung, Hye-LimYang, Sung-YongPyo, Min CheolHong, Chung-OuiNam, Mi-HyunLee, Jin-WonLee, Kwang-Won
Issue Date
4월-2019
Publisher
KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
Keywords
Chebulic acid; Nuclear factor erythroid 2-related factor 2; Heme oxygenase-1; -Glutamate cysteine ligase; Mitogen-activated protein kinases
Citation
FOOD SCIENCE AND BIOTECHNOLOGY, v.28, no.2, pp.555 - 562
Indexed
SCIE
SCOPUS
KCI
Journal Title
FOOD SCIENCE AND BIOTECHNOLOGY
Volume
28
Number
2
Start Page
555
End Page
562
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/66455
DOI
10.1007/s10068-018-0477-z
ISSN
1226-7708
Abstract
Although chebulic acid isolated from Terminalia chebular has diverse biological effects, its effects on the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and the expression of downstream genes have not been elucidated. The purpose of this research is to investigate the hepatoprotective mechanism of chebulic acid against oxidative stress produced by tert-butyl hydroperoxide (t-BHP) in liver cells. The treatment with chebulic acid attenuated cell death in t-BHP-induced HepG2 liver cells and increased intracellular glutathione content, upregulated the activity of heme oxygenase-1, and also increased the translocation of Nrf2 into the nucleus and Nrf2 target gene expression in a dose-dependent manner. The exposure of chebulic acid activated the phosphorylation of mitogen-activated protein kinases. The overall result is that chebulic acid has cytoprotective effect on t-BHP-induced hepatotoxicity in HepG2 cells through Nrf2-mediated antioxidant enzymes.
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