Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones
- Authors
- Park, Je Won; Yoon, Yeo Joon
- Issue Date
- Mar-2019
- Publisher
- SPRINGER HEIDELBERG
- Keywords
- 14-Membered macrolide; Polyketide synthase; Post-polyketide synthase tailoring; Combinatorial biosynthesis
- Citation
- JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, v.46, no.3-4, pp.445 - 458
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Volume
- 46
- Number
- 3-4
- Start Page
- 445
- End Page
- 458
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/67085
- DOI
- 10.1007/s10295-018-2095-4
- ISSN
- 1367-5435
- Abstract
- Macrolides, especially 14-membered macrolides, are a valuable group of antibiotics that originate from various microorganisms. In addition to their antibacterial activity, newly discovered 14-membered macrolides exhibit other therapeutic potentials, such as anti-proliferative and anti-protistal activities. Combinatorial biosynthetic approaches will allow us to create structurally diversified macrolide analogs, which are especially important during the emerging post-antibiotic era. This review focuses on recent advances in the discovery of new 14-membered macrolides (also including macrolactones) from microorganisms and the current status of combinatorial biosynthetic approaches, including polyketide synthase (PKS) and post-PKS tailoring pathways, and metabolic engineering for improved production together with heterologous production of 14-membered macrolides.
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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