Evolutionary relationship analysis of Middle East respiratory syndrome coronavirus 4a and 4b protein coding sequences
- Authors
- Kim, Jin Il; Park, Sehee; Bae, Joon-Yong; Park, Man-Seong
- Issue Date
- Mar-2019
- Publisher
- KOREAN SOC VETERINARY SCIENCE
- Keywords
- Middle East respiratory syndrome coronavirus; molecular evolution; phylogeny; zoonoses
- Citation
- JOURNAL OF VETERINARY SCIENCE, v.20, no.2
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF VETERINARY SCIENCE
- Volume
- 20
- Number
- 2
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/67130
- DOI
- 10.4142/jvs.2019.20.e1
- ISSN
- 1229-845X
- Abstract
- The 4a and 4b proteins of the Middle East respiratory syndrome coronavirus (MERS-CoV) have been described for their antagonism on host innate immunity. However, unlike clustering patterns of the complete gene sequences of human and camel MERS-CoVs, the 4a and 4b protein coding regions did not constitute species-specific phylogenetic groups. Moreover, given the estimated evolutionary rates of the complete, 4a, and 4b gene sequences, the 4a and 4b proteins might be less affected by species-specific innate immune pressures. These results suggest that the 4a and 4b proteins of MERS-CoV may function against host innate immunity in a manner independent of host species and/or evolutionary clustering patterns.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholar.korea.ac.kr/handle/2021.sw.korea/67130)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.