Pluronics: Intelligent building units for targeted cancer therapy and molecular imaging
- Authors
- Ul Khaliq, Nisar; Park, Dal Yong; Yun, Byeong Min; Yang, Da Hye; Jung, Yong Woo; Seo, Jae Hong; Hwang, Chang Soon; Yuk, Soon Hong
- Issue Date
- 10-Feb-2019
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Pluronic nanoparticles; Phase transition; Small molecules; Macromolecules; Doxorubicin; In situ gel
- Citation
- INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.556, pp.30 - 44
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Volume
- 556
- Start Page
- 30
- End Page
- 44
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/67645
- DOI
- 10.1016/j.ijpharm.2018.11.064
- ISSN
- 0378-5173
- Abstract
- Pluronics are triblock copolymers, in which two hydrophilic poly (ethylene oxide) (PEO) blocks are connected via a hydrophobic poly propylene oxide (PPO) block. Because of their low molecular weight and high content of PEO, Pluronics have demonstrated the micellization phenomenon, which is dependent on temperature and/or concentration. With an understanding of micellization phenomenon in more detail, information on the morphology, micelle core radius, aggregation behavior with critical micelle concentration (CMC) and critical micelle temperature (CMT) and so on has been revealed. Based on this acquired information, various studies have been performed for biomedical applications such as drug delivery systems, tissue regeneration scaffolders, and biosurfactants. This review discusses the delivery of small molecules and macromolecules using Pluronic-based NPs and their composites.
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- Appears in
Collections - College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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