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Apoptotic changes in a full-lengthened immobilization model of rat soleus muscle

Authors
Suh, Hye RimPark, Eui HoMoon, Sun WookKim, Ji WonCho, Hwi YoungHan, Hee Chul
Issue Date
2월-2019
Publisher
WILEY
Keywords
apoptosis; Bax; casting; lengthened immobilization; lengthening; soleus
Citation
MUSCLE & NERVE, v.59, no.2, pp.263 - 269
Indexed
SCIE
SCOPUS
Journal Title
MUSCLE & NERVE
Volume
59
Number
2
Start Page
263
End Page
269
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/67791
DOI
10.1002/mus.26359
ISSN
0148-639X
Abstract
Introduction: Lengthened immobilization may prevent muscle shortening, and help maintain normal muscle length. However, its apoptotic effects remain unclear. We evaluated the effects of long-term immobilization on apoptotic proteins. Methods: Rat soleus muscles were immobilized by casting in a neutral (NEUT) or lengthened (LENG) position for 21 days. We evaluated dynamic weight load and muscle atrophy following the 21-day period using hematoxylin and eosin staining. We measured Bax (pro-apoptotic Bcl-2 family member), MyoD (myogenic differentiation factor D), MYH (myosin heavy chain), and cleaved poly(ADP-ribose)polymerase levels and examined apoptotic nucleus expression. Results: Decreased dynamic weight load and muscle atrophy changes were observed in LENG. Both NEUT and LENG showed significantly reduced levels of MYH. LENG showed a significant increase in Bax and MyoD expression as well as in the number of apoptotic nuclei. Conclusions: Long-term lengthened immobilization may increase apoptotic changes and decrease muscle formation proteins in muscle. Muscle Nerve 59:263-269, 2019
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