Optical stimulation of cardiac cells with a polymer-supported silicon nanowire matrix
- Authors
- Parameswaran, Ramya; Koehler, Kelliann; Rotenberg, Menahem Y.; Burke, Michael J.; Kim, Jungkil; Jeong, Kwang-Yong; Hissa, Barbara; Paul, Michael D.; Moreno, Kiela; Sarma, Nivedina; Hayes, Thomas; Sudzilovsky, Edward; Park, Hong-Gyu; Tian, Bozhi
- Issue Date
- 8-1월-2019
- Publisher
- NATL ACAD SCIENCES
- Keywords
- cardiac; silicon; nanowire; modulation; optical
- Citation
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.116, no.2, pp.413 - 421
- Indexed
- SCIE
SCOPUS
- Journal Title
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Volume
- 116
- Number
- 2
- Start Page
- 413
- End Page
- 421
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/68314
- DOI
- 10.1073/pnas.1816428115
- ISSN
- 0027-8424
- Abstract
- Electronic pacemakers can treat electrical conduction disorders in hearts; however, they are invasive, bulky, and linked to increased incidence of infection at the tissue-device interface. Thus, researchers have looked to other more biocompatible methods for cardiac pacing or resynchronization, such as femtosecond infrared light pulsing, optogenetics, and polymer-based cardiac patches integrated with metal electrodes. Here we develop a biocompatible nongenetic approach for the optical modulation of cardiac cells and tissues. We demonstrate that a polymer-silicon nanowire composite mesh can be used to convert fast moving, low-radiance optical inputs into stimulatory signals in target cardiac cells. Our method allows for the stimulation of the cultured cardiomyocytes or ex vivo heart to beat at a higher target frequency.
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Collections - College of Science > Department of Physics > 1. Journal Articles
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