pH-dependent regulation of SQSTM1/p62 during autophagy
- Authors
- Kwon, Do Hoon; Kim, Leehyeon; Song, Hyun Kyu
- Issue Date
- 2-1월-2019
- Publisher
- TAYLOR & FRANCIS INC
- Keywords
- Aggrephagy; autophagy adaptor; HSPA5/BiP/GRP78; N-end rule; pH-dependent oligomerization; UBR box
- Citation
- AUTOPHAGY, v.15, no.1, pp.180 - 181
- Indexed
- SCIE
SCOPUS
- Journal Title
- AUTOPHAGY
- Volume
- 15
- Number
- 1
- Start Page
- 180
- End Page
- 181
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/68347
- DOI
- 10.1080/15548627.2018.1532264
- ISSN
- 1554-8627
- Abstract
- During macroautophagy/autophagy, SQSTM1/p62 plays dual roles as a key mediator of cargo selection and as an autophagic substrate. SQSTM1 links N-degrons and/or ubiquitinated cargoes to the autophagosome by forming homo- or hetero-oligomers, although its N-degron recognition and oligomerization mechanisms are not well characterized. We recently found that SQSTM1 is a novel type of N-recognin whose ZZ domain provides a negatively-charged binding pocket for Arg-charged N-degron (Nt-Arg), a prototype type-1 substrate. Although differences in binding affinity exist for each N-degron, SQSTM1 also interacts with type-2 N-degrons, such as Nt-Tyr and Nt-Trp. Intriguingly, interactions between SQSTM1's ZZ domain and various N-degrons are greatly influenced by pH-dependent SQSTM1 oligomerization via its PB1 domain. Because cellular pH conditions vary from neutral to acidic depending on the stage of autophagy, the pH-dependent regulation of SQSTM1's oligomerization must be tightly coupled with the autophagic process.
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Collections - Graduate School > Department of Life Sciences > 1. Journal Articles
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