Early Vitamin C and Thiamine Administration to Patients with Septic Shock in Emergency Departments: Propensity Score-Based Analysis of a Before-and-After Cohort Study
- Authors
- Shin, Tae Gun; Kim, Youn-Jung; Ryoo, Seung Mok; Hwang, Sung Yeon; Jo, Ik Joon; Chung, Sung Phil; Choi, Sung-Hyuk; Suh, Gil Joon; Kim, Won Young
- Issue Date
- 1월-2019
- Publisher
- MDPI
- Keywords
- sepsis; septic shock; thiamine; vitamin C; resuscitation
- Citation
- JOURNAL OF CLINICAL MEDICINE, v.8, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CLINICAL MEDICINE
- Volume
- 8
- Number
- 1
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/68811
- DOI
- 10.3390/jcm8010102
- ISSN
- 2077-0383
- Abstract
- Background: Intravenous vitamin C and thiamine administration may be a potential adjuvant therapy for septic shock. We aimed to investigate the impact of early vitamin C and thiamine administration in septic shock patients. Methods: This retrospective before-and-after cohort study used data extracted from the Korean Shock Society's prospective septic shock registry. We compared 28-day and in-hospital mortality rates between patients treated with intravenous vitamin C (3 g/12 h or 1.5 g/6 h) and thiamine (200 mg/12 h) <6 h after shock recognition from July through December 2017 (n = 229) and control patients from October 2015 through June 2017 (n = 915) using propensity score matching. Results: The 28-day (18.3% vs. 17.5%; p = 0.76) and in-hospital (16.6% vs. 18.3%; p = 0.55) mortality rates did not differ between treatment and control groups, nor did 28-day (18.5% vs. 17.5%; p = 0.84) and in-hospital (16.7% vs. 18.4%; p = 0.54) mortality rates after matching. In the subgroup analysis, treatment was associated with lower in-hospital mortality rates in patients with albumin <3.0 mg/dL or a Sequential Organ Failure Assessment (SOFA) score >10. Conclusion: Early vitamin C and thiamine administration in patients with septic shock did not improve survival; however, administration could benefit conditions that are more severe, such as hypoalbuminemia or severe organ failure.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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