Fructose-1,6-bisphosphatase Inhibitors: A Review of Recent (2000-2017) Advances and Structure-Activity Relationship Studies
- Authors
- Singh, Sarbjit; Harmalkar, Dipesh S.; Choi, Yongseok; Lee, Kyeong
- Issue Date
- 2019
- Publisher
- BENTHAM SCIENCE PUBL LTD
- Keywords
- Fructose-1,6-bisphosphatase inhibitors; type 2 diabetes; adenosine 5 ' -monophosphate; hyperglycemia; diabetes mellitus; chronic disease
- Citation
- CURRENT MEDICINAL CHEMISTRY, v.26, no.29, pp.5542 - 5563
- Indexed
- SCIE
SCOPUS
- Journal Title
- CURRENT MEDICINAL CHEMISTRY
- Volume
- 26
- Number
- 29
- Start Page
- 5542
- End Page
- 5563
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/69011
- DOI
- 10.2174/0929867325666180831133734
- ISSN
- 0929-8673
- Abstract
- Diabetes mellitus, commonly referred to as diabetes, is the 8th leading cause of death worldwide. As of 2015, approximately 415 million people were estimated to be diabetic worldwide, type 2 diabetes being the most common accounting for approximately 90-95% of all diagnosed cases with increasing prevalence. Fructose-1,6-bisphosphatase is one of the important therapeutic targets recently discovered to treat this chronic disease. In this focused review, we have highlighted recent advances and structure-activity relationship studies in the discovery and development of different fructose-1,6-bisphosphatase inhibitors reported since the year 2000.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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