Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jo, Kyungae | - |
dc.contributor.author | Kim, Hoon | - |
dc.contributor.author | Choi, Hyeon-Son | - |
dc.contributor.author | Lee, Seung-Su | - |
dc.contributor.author | Bang, Myun-Ho | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.date.accessioned | 2021-09-02T02:36:56Z | - |
dc.date.available | 2021-09-02T02:36:56Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-12 | - |
dc.identifier.issn | 1226-7708 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/71427 | - |
dc.description.abstract | The aim of this study was to identify sleep-promoting substance from Polygonatum sibiricum rhizome extract (PSE) with the regulation of sleep architecture. PSE showed a decrease in sleep latency time and an increase in the sleeping time. In the electroencephalography analysis of rats, PSE (150mg/kg) showed an increase of non-rapid eye movement by 38% and a decrease of rapid eye movement by 31% compared to the control. This sleep-promoting activity was found to be involved in the GABA(A)-BDZ receptor. The chemical structure of the pure compound was determined by the H-1 and C-13 nuclear magnetic resonance spectroscopy and gas chromatography mass spectrometry analysis; active compound was glyceryl-1-monolinoleate. The commercial standard glyceryl-1-monolinoleate showed a similar inhibitory concentration on [H-3]-flumazenil binding to GABA(A)-BDZ receptors with final active fraction of PSE. The results indicate that glyceryl-1-monolinoleate is a major active compound responsible for the PSE-derived sleep promotion. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST | - |
dc.subject | PENTOBARBITAL-INDUCED SLEEP | - |
dc.subject | FATTY-ACIDS | - |
dc.subject | IN-VITRO | - |
dc.subject | OLEAMIDE | - |
dc.subject | DROSOPHILA | - |
dc.subject | MEDICINE | - |
dc.subject | EXTRACTS | - |
dc.subject | MICE | - |
dc.subject | MODULATION | - |
dc.subject | RECEPTORS | - |
dc.title | Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jo, Kyungae | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.1007/s10068-018-0431-0 | - |
dc.identifier.scopusid | 2-s2.0-85049846230 | - |
dc.identifier.wosid | 000450102900031 | - |
dc.identifier.bibliographicCitation | FOOD SCIENCE AND BIOTECHNOLOGY, v.27, no.6, pp.1833 - 1842 | - |
dc.relation.isPartOf | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.citation.title | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.citation.volume | 27 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1833 | - |
dc.citation.endPage | 1842 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002415326 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | PENTOBARBITAL-INDUCED SLEEP | - |
dc.subject.keywordPlus | FATTY-ACIDS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | OLEAMIDE | - |
dc.subject.keywordPlus | DROSOPHILA | - |
dc.subject.keywordPlus | MEDICINE | - |
dc.subject.keywordPlus | EXTRACTS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordAuthor | Glyceryl monolinoleate | - |
dc.subject.keywordAuthor | Polygonatum sibiricum | - |
dc.subject.keywordAuthor | Insomnia | - |
dc.subject.keywordAuthor | Sleep | - |
dc.subject.keywordAuthor | GABA type A-benzodiazepine receptor | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.