Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome
- Authors
- Jo, Kyungae; Kim, Hoon; Choi, Hyeon-Son; Lee, Seung-Su; Bang, Myun-Ho; Suh, Hyung Joo
- Issue Date
- 12월-2018
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- Glyceryl monolinoleate; Polygonatum sibiricum; Insomnia; Sleep; GABA type A-benzodiazepine receptor
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.27, no.6, pp.1833 - 1842
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 27
- Number
- 6
- Start Page
- 1833
- End Page
- 1842
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/71427
- DOI
- 10.1007/s10068-018-0431-0
- ISSN
- 1226-7708
- Abstract
- The aim of this study was to identify sleep-promoting substance from Polygonatum sibiricum rhizome extract (PSE) with the regulation of sleep architecture. PSE showed a decrease in sleep latency time and an increase in the sleeping time. In the electroencephalography analysis of rats, PSE (150mg/kg) showed an increase of non-rapid eye movement by 38% and a decrease of rapid eye movement by 31% compared to the control. This sleep-promoting activity was found to be involved in the GABA(A)-BDZ receptor. The chemical structure of the pure compound was determined by the H-1 and C-13 nuclear magnetic resonance spectroscopy and gas chromatography mass spectrometry analysis; active compound was glyceryl-1-monolinoleate. The commercial standard glyceryl-1-monolinoleate showed a similar inhibitory concentration on [H-3]-flumazenil binding to GABA(A)-BDZ receptors with final active fraction of PSE. The results indicate that glyceryl-1-monolinoleate is a major active compound responsible for the PSE-derived sleep promotion.
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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