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Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity
- Authors
- Singh, Hardev; Kim, Seo Jin; Kang, Dong Hoon; Kim, Hye-Ri; Sharma, Amit; Kim, Won Young; Kang, Chulhun; Kim, Jong Seung
- Issue Date
- 11-Nov-2018
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.54, no.87, pp.12353 - 12356
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 54
- Number
- 87
- Start Page
- 12353
- End Page
- 12356
- ISSN
- 1359-7345
- Abstract
- Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic counterparts significantly enhanced their HCC targeting ability and excellent therapeutic efficacy.
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Related Researcher
- Kim, Jong Seung
- College of Science (Department of Chemistry)