Antimicrobial activity of NO-releasing compounds against periodontal pathogens
- Authors
- Shim, Ji Suk; Park, Dong-sik; Baek, Dong-Heon; Jha, Nayansi; Park, Serk In; Yun, Hyoung Jin; Kim, Won Jong; Ryu, Jae Jun
- Issue Date
- 4-10월-2018
- Publisher
- PUBLIC LIBRARY SCIENCE
- Citation
- PLOS ONE, v.13, no.10
- Indexed
- SCIE
SCOPUS
- Journal Title
- PLOS ONE
- Volume
- 13
- Number
- 10
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/72514
- DOI
- 10.1371/journal.pone.0199998
- ISSN
- 1932-6203
- Abstract
- This study describes the successful synthesis of nitric oxide (NO)-releasing compounds with biodegradable and injectable properties and demonstrates that the kinetics of NO release vary according to the type of NO donor. The antimicrobial activity of NO-releasing compounds against three common periodontal pathogens, i.e., Aggregatibacter actinomy-cetemcomitans, Porphyromonas gingivalis, and Actinomyces israelii, was investigated using a susceptibility assay. Human gingival fibroblasts were treated with NO-releasing compounds at the minimum concentrations required for bacterial growth and cytotoxicity was evaluated using the MTT cell proliferation assay. Our results suggest that NO-releasing compounds can be used topically to treat both gram-negative and gram-positive periodontal pathogens. Comparison of the antimicrobial activity and cytotoxicity assay results between the NO-releasing compounds revealed that an NO donor comprising a macromolecule without surface charge, a lower instantaneous NO concentration, and an adequate supply of NO were associated with a strong bactericidal effect and low cytotoxicity. NO-releasing compounds with these properties may be suitable for treatment of periodontitis.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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