Vitamin D level and risk of systemic lupus erythematosus and rheumatoid arthritis: a Mendelian randomization
- Authors
- Bae, Sang-Cheol; Lee, Young Ho
- Issue Date
- 9월-2018
- Publisher
- SPRINGER LONDON LTD
- Keywords
- Mendelian randomization; RA; SLE; Telomere length
- Citation
- CLINICAL RHEUMATOLOGY, v.37, no.9, pp.2415 - 2421
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL RHEUMATOLOGY
- Volume
- 37
- Number
- 9
- Start Page
- 2415
- End Page
- 2421
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/73681
- DOI
- 10.1007/s10067-018-4152-9
- ISSN
- 0770-3198
- Abstract
- The aim of this study was to examine whether the vitamin D level is causally associated with risk of systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). We performed two-sample Mendelian randomization (MR) analyses using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods on publicly available summary statistics datasets using two vitamin D level genome-wide association studies (GWASs) as exposure and SLE and RA GWASs on people of European descent as outcomes. We selected three independent single-nucleotide polymorphisms located at SSTR4 (rs2207173), GC (rs2282679), and NADSYN1 (3829251) with gnome-wide significance from two GWASs on vitamin D levels as instrumental variables. The IVW, weighted median, and MR-Egger regression methods yielded no evidence of a causal association between vitamin D level and risk of SLE (beta = 0.032, SE = 0.119, p = 0.789; beta = 0.233, SE = 0.274, p = 0.552; beta = 0.054, SE = 0.125, p = 0.665; respectively) or RA (beta = 0.026, SE = 0.061, p = 0.664; beta = 0.025, SE = 0.065, p = 0.695; beta = 0.025, SE = 0.065, p = 0.695; respectively). In addition, MR-Egger regression revealed directional pleiotropy was unlikely to be biasing the result for SLE (intercept = - 0.058, p = 0.545) or RA (intercept = - 0.027, p = 0.558). The MR estimates from IVW, weighted median, and MR-Egger regression analyses were consistent. MR analysis did not support a causal association between the vitamin D level and SLE or RA.
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