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Modulating the GSH/Trx selectivity of a fluorogenic disulfide-based thiol sensor to reveal diminished GSH levels under ER stress
- Authors
- Wi, Youngjin; Le, Hoa Thi; Verwilst, Peter; Sunwoo, Kyoung; Kim, Seo Jin; Song, Jung Eun; Yoon, Hey Young; Han, Geon; Kim, Jong Seung; Kang, Chulhun; Kim, Tae Woo
- Issue Date
- 18-8월-2018
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.54, no.64, pp.8897 - 8900
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 54
- Number
- 64
- Start Page
- 8897
- End Page
- 8900
- ISSN
- 1359-7345
- Abstract
- We synthesized a fluorogenic disulfide-based naphthalimide thiol probe (ER-Naph) with a hydrophilic endoplasmic reticulum (ER)-guiding glibenclamide unit. Its ER targeting ability and high selectivity to GSH over thioredoxin, a potent competitor, were clearly demonstrated, both in solution and in vitro. Finally, a confocal microscopic investigation revealed that GSH levels in the ER were dramatically decreased under thapsigargin, brefeldin A, and tunicamycin-induced ER stress models.
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