Synergistic effect of Korean red ginseng and Pueraria montana var. lobata against trimethyltin-induced cognitive impairment
- Authors
- Seo, Young-Min; Choi, Soo Jung; Park, Chan Kyu; Gim, Min Chul; Shin, Dong-Hoon
- Issue Date
- 8월-2018
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- Alzheimer' s disease; Learning; Memory; Pueraria montana var. lobata; Red ginseng
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.27, no.4, pp.1193 - 1200
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 27
- Number
- 4
- Start Page
- 1193
- End Page
- 1200
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/74269
- DOI
- 10.1007/s10068-018-0362-9
- ISSN
- 1226-7708
- Abstract
- Many edible plant extracts exhibit biological activities. For example, the ethanol extract of Pueraria montana var. lobata (P. montana) inhibits acetylcholinesterase (AChE), and red ginseng is well known for promoting health. In this study the authors investigated the synergistic effect of P. montana and red ginseng extracts on AChE activity in vitro and in mouse brain tissues and trimethyltin (TMT)-induced cognitive impairment in a mouse model of TMT-induced neurodegeneration. A diet containing a mixture of P. montana and red ginseng extracts reversed learning and memory impairments in Y-maze and passive avoidance behavioral tests. In addition, the mixture inhibited AChE activity and lipid peroxidation synergistically.
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Collections - College of Science and Technology > Department of Food and Biotechnology > 1. Journal Articles
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