Effects of Cornus walteri extract on hepatic lipid-regulating enzyme activities in high fat diet-induced obese rats
- Authors
- Yun, Sung Ho; Lee, Junsoo; Suh, Hyung Joo; Jung, Eun Young
- Issue Date
- 7월-2018
- Publisher
- MATTIOLI 1885
- Keywords
- body fat; Cornus walteri; glucose-6-phosphate dehydrogenase; malic enzyme; carnitine palmitoyltransferase
- Citation
- PROGRESS IN NUTRITION, v.20, pp.39 - 45
- Indexed
- SCIE
SCOPUS
- Journal Title
- PROGRESS IN NUTRITION
- Volume
- 20
- Start Page
- 39
- End Page
- 45
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/74466
- DOI
- 10.23751/pn.v20i1-S.5237
- ISSN
- 1129-8723
- Abstract
- In this study, we investigated whether the body fat suppressive effects of Cornus walteri extract (CE) were due to alterations in lipid-regulating enzyme activities in high fat diet-induced obese rats. Male Sprague-Dawley rats were randomly divided into three groups (n=6): a normal diet group (N-control), a high fat diet group (F-control), and a high fat diet group, treated orally with CE (0.25%) in their drinking water (Treatment). After five weeks, CE supplementation tended to reduce body-weight gain and visceral fat in the diet-induced obese rats. Tie activity of hepatic glucose-6-phosphate dehydrogenase (G6PD) and malic enzyme (ME), responsible for fatty acid synthesis, tended to be lower in the Treatment group compared to the non-treated groups. This finding indicates that the body fat suppressive effects of CE are most likely due to decreases in hepatic fatty acid synthesis. CE supplementation increased hepatic carnitine palmitoyltransferase (CPT) activity, which suggests that beta-oxidation was enhanced. In conclusion, CE supplementation suppressed body fat accumulation by attenuating fatty acid synthesis and enhancing beta-oxidation through alteration of lipid-regulating enzyme activities.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.