Effect of electronic cigarettes on human middle ear
- Authors
- Song, Jae-Jun; Go, Yoon Young; Mun, Ji Yoen; Lee, Sehee; Im, Gi Jung; Kim, Yoo Yon; Lee, Jun Ho; Chang, Jiwon
- Issue Date
- 6월-2018
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Electronic cigarette; Heavy metals; Cytotoxicity; Human middle ear epithelial cells; Otitis media
- Citation
- INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, v.109, pp.67 - 71
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
- Volume
- 109
- Start Page
- 67
- End Page
- 71
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/75071
- DOI
- 10.1016/j.ijporl.2018.03.028
- ISSN
- 0165-5876
- Abstract
- Objective: Electronic cigarettes (e-cigarettes) are the most commonly used electronic nicotine delivery systems and are a relatively new product designed for smoking cessation. The market scale of electronic cigarettes is growing rapidly, but the potential impact of e-cigarettes on public health has not yet been verified. In this study, we examined the effect of e-liquids on a human middle ear epithelial cell (HMEEC) line. Material and methods: The main components of e-liquids are propylene glycol, vegetable glycerin and flavoring agents with or without nicotine. We analyzed 73 bottles of e-liquids from 12 different manufacturers, evaluated the trace elements in e-liquids, and identified the cytotoxicity of e-liquids on HMEECs in the presence or absence of nicotine. Results: In the trace elements analysis, nickel, arsenic, cadmium, and lead were detected in the e-liquids. E-liquids without nicotine decreased cell viability, and the average IC50 value of total e-liquids (n = 73) was 2.48 +/- 0.93%. Among the different flavors, menthol-flavored e-liquids significantly reduced cell viability, and their average IC50 value (n = 28) was 1.85 +/- 0.80%. The average IC50 values were distinct among manufacturers and the proportion of the solvents. Conclusion: The present study provides evidence that e-cigarettes influence and reduce human middle ear cell viability even without the application of nicotine. Additionally, the cytotoxicity of e-liquids was affected by the flavoring agents.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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