Two combined amino acids promote sleep activity in caffeine-induced sleepless model systems
DC Field | Value | Language |
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dc.contributor.author | Hong, Ki-Bae | - |
dc.contributor.author | Park, Yooheon | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.date.accessioned | 2021-09-02T11:13:08Z | - |
dc.date.available | 2021-09-02T11:13:08Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.issn | 1976-1457 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/75398 | - |
dc.description.abstract | BACKGROUND/OBJECTIVES: The aim of this study was to evaluate the biological and sleep-promoting effects of combined gamma-aminobutyric acid (GABA) and 5-hydroxytryptophan (5-HTP) using caffeine-induced sleepless fruit flies, ICR mice, and Sprague-Dawley rats. MATERIALS/METHODS: Video-tracking analysis was applied to investigate behavioral changes of Drosophila melanogaster. Pentobarbital-induced sleep test and electroencephalogram (EEG) patterns were used for analysis of sleep latency, duration, and quantity and quality of sleep in vertebrate models. RESULTS: Administration of combined GABA/5-HTP could significantly reverse the caffeine induced total distance of flies (P < 0.001). Also, individually administered and combined GABA/5-HTP significantly increased the total sleeping time in the caffeine-induced sleepless ICR mice (P < 0.001). In the caffeine-induced sleepless SD-rats, combined GABA/5-HTP showed significant differences in sleep quality between individual amino acid administrations (P < 0.05). CONCLUSIONS: Taken together, we identified inhibitory effects of combined GABA/5-HTP in locomotor activity, sleep quantity and quality in caffeine-induced sleepless models, indicating that combined GABA/5-HTP may be effective in patients with insomnia by providing sufficient sleep. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN NUTRITION SOC | - |
dc.subject | DROSOPHILA-MELANOGASTER | - |
dc.subject | GABA/5-HTP MIXTURE | - |
dc.subject | GABA(B) RECEPTORS | - |
dc.subject | SEROTONIN | - |
dc.subject | MICE | - |
dc.subject | INSOMNIA | - |
dc.subject | RATS | - |
dc.subject | BEHAVIORS | - |
dc.subject | TRANSPORT | - |
dc.subject | ADENOSINE | - |
dc.title | Two combined amino acids promote sleep activity in caffeine-induced sleepless model systems | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.4162/nrp.2018.12.3.208 | - |
dc.identifier.scopusid | 2-s2.0-85048170752 | - |
dc.identifier.wosid | 000434371000004 | - |
dc.identifier.bibliographicCitation | NUTRITION RESEARCH AND PRACTICE, v.12, no.3, pp.208 - 214 | - |
dc.relation.isPartOf | NUTRITION RESEARCH AND PRACTICE | - |
dc.citation.title | NUTRITION RESEARCH AND PRACTICE | - |
dc.citation.volume | 12 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 208 | - |
dc.citation.endPage | 214 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002349232 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | DROSOPHILA-MELANOGASTER | - |
dc.subject.keywordPlus | GABA/5-HTP MIXTURE | - |
dc.subject.keywordPlus | GABA(B) RECEPTORS | - |
dc.subject.keywordPlus | SEROTONIN | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | INSOMNIA | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | BEHAVIORS | - |
dc.subject.keywordPlus | TRANSPORT | - |
dc.subject.keywordPlus | ADENOSINE | - |
dc.subject.keywordAuthor | Sleep | - |
dc.subject.keywordAuthor | caffeine | - |
dc.subject.keywordAuthor | GABA | - |
dc.subject.keywordAuthor | 5-HTP | - |
dc.subject.keywordAuthor | insomnia | - |
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