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Two combined amino acids promote sleep activity in caffeine-induced sleepless model systems

Authors
Hong, Ki-BaePark, YooheonSuh, Hyung Joo
Issue Date
6월-2018
Publisher
KOREAN NUTRITION SOC
Keywords
Sleep; caffeine; GABA; 5-HTP; insomnia
Citation
NUTRITION RESEARCH AND PRACTICE, v.12, no.3, pp.208 - 214
Indexed
SCIE
SCOPUS
KCI
Journal Title
NUTRITION RESEARCH AND PRACTICE
Volume
12
Number
3
Start Page
208
End Page
214
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/75398
DOI
10.4162/nrp.2018.12.3.208
ISSN
1976-1457
Abstract
BACKGROUND/OBJECTIVES: The aim of this study was to evaluate the biological and sleep-promoting effects of combined gamma-aminobutyric acid (GABA) and 5-hydroxytryptophan (5-HTP) using caffeine-induced sleepless fruit flies, ICR mice, and Sprague-Dawley rats. MATERIALS/METHODS: Video-tracking analysis was applied to investigate behavioral changes of Drosophila melanogaster. Pentobarbital-induced sleep test and electroencephalogram (EEG) patterns were used for analysis of sleep latency, duration, and quantity and quality of sleep in vertebrate models. RESULTS: Administration of combined GABA/5-HTP could significantly reverse the caffeine induced total distance of flies (P < 0.001). Also, individually administered and combined GABA/5-HTP significantly increased the total sleeping time in the caffeine-induced sleepless ICR mice (P < 0.001). In the caffeine-induced sleepless SD-rats, combined GABA/5-HTP showed significant differences in sleep quality between individual amino acid administrations (P < 0.05). CONCLUSIONS: Taken together, we identified inhibitory effects of combined GABA/5-HTP in locomotor activity, sleep quantity and quality in caffeine-induced sleepless models, indicating that combined GABA/5-HTP may be effective in patients with insomnia by providing sufficient sleep.
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Suh, Hyung Joo
보건과학대학 (바이오시스템의과학부)
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