Sustained exenatide delivery via intracapsular microspheres for improved survival and function of microencapsulated porcine islets
- Authors
- Lew, Benjamin; Kim, In-Yong; Choi, Hyungsoo; Kim, Kyekyoon (Kevin)
- Issue Date
- 6월-2018
- Publisher
- SPRINGER HEIDELBERG
- Keywords
- Porcine islets; Exenatide; Microspheres; Microcapsules; Islet encapsulation; Islet xenotransplantation
- Citation
- DRUG DELIVERY AND TRANSLATIONAL RESEARCH, v.8, no.3, pp.857 - 862
- Indexed
- SCIE
SCOPUS
- Journal Title
- DRUG DELIVERY AND TRANSLATIONAL RESEARCH
- Volume
- 8
- Number
- 3
- Start Page
- 857
- End Page
- 862
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/75467
- DOI
- 10.1007/s13346-018-0484-x
- ISSN
- 2190-393X
- Abstract
- The ability of glucagon-like peptide-1 analogs to enhance glucose-dependent insulin secretion and to inhibit beta cell apoptosis could be of potential benefit for islet transplantation. In this study, we investigated the effect of sustained local delivery of exenatide, a synthetic exendin-4, on the in vitro viability and function of encapsulated porcine islets. Prior to encapsulation, we fabricated exenatide-loaded poly(latic-co-glycolic acid) microspheres, and investigated their release behavior with different initial drug-loading amounts. Exenatide-loaded microspheres, exhibiting a sustained release over 21 days, were subsequently chosen and co-encapsulated with porcine islets in alginate microcapsules. During the 21-day period, the islets co-encapsulated with the exenatide-loaded microspheres exhibited improved survival and glucose-stimulated insulin secretion, compared to those without. This suggested that the intracapsular sustained delivery of exenatide via microspheres could be a promising strategy for improving survival and function of microencapsulated porcine islets for islet xenotransplantation.
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