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Melanogenesis inhibitory pregnane glycosides from Cynanchum atratum
- Authors
- Jin, Qinghao; Han, Xiang Hua; Yun, Cheong-Yong; Lee, Chul; Lee, Jin Woo; Lee, Dongho; Lee, Mi Kyeong; Jung, Sang-Hun; Hong, Jin Tae; Kim, Youngsoo; Hwang, Bang Yeon
- Issue Date
- 15-Apr-2018
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Cynanchum atratum; Asclepiadaceae; Pregnane glycosides; alpha-MSH; Melanogenesis inhibitor
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.28, no.7, pp.1252 - 1256
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 28
- Number
- 7
- Start Page
- 1252
- End Page
- 1256
- ISSN
- 0960-894X
- Abstract
- Bioassay-guided fractionation of the methanolic extract from the roots of Cynanchum atratum has resulted in the isolation of three new pregnane glycosides (1-3) along with four known compounds (4-7). Their structures were identified by analysis of the spectroscopic data including extensive 2D NMR. All of the isolates were evaluated for their potential to inhibit the melanin production in a-melanocyte stimulating hormone (alpha-MSH)-activated B16 melanoma cells. Of these, compounds 4-7 dosedependently inhibited the melanin production with the IC50 values ranging from 4 mu M to 33 mu M. (C) 2018 Elsevier Ltd. All rights reserved.
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Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology