Capillary rarefaction and altered renal development: the imbalance between pro- and anti-angiogenic factors in response to angiotensin II inhibition in the developing rat kidney
- Authors
- Yoo, Kee Hwan; Yim, Hyung Eun; Bae, Eun Soo; Hong, Young Sook
- Issue Date
- 4월-2018
- Publisher
- SPRINGER
- Keywords
- Angiopoietins; Neovascularization; Pathologic; Renin-angiotensin system; Thrombospondin-1
- Citation
- JOURNAL OF MOLECULAR HISTOLOGY, v.49, no.2, pp.219 - 228
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF MOLECULAR HISTOLOGY
- Volume
- 49
- Number
- 2
- Start Page
- 219
- End Page
- 228
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/76624
- DOI
- 10.1007/s10735-018-9762-7
- ISSN
- 1567-2379
- Abstract
- Proper and timely assembly of the kidney vasculature with their respective nephrons is crucial during normal kidney development. In this study, we investigated the effects of enalapril (angiotensin-converting enzyme inhibitor) on angiogenesis-related gene expression and microvascular endothelium related to glomeular and tubular changes in the neonatal rat kidney. Enalapril-treated rats had higher tubular injury scores and lower glomerular maturity grades than those of untreated rats. In the enalapril-treated group, intrarenal angiopoietin-2, Tie-2, and thrombospondin-1 protein expression increased, whereas intrarenal angiopoietin-1 protein expression decreased. JG12-positive glomerular and peritubular capillary staining was reduced in the enalapril-treated rat kidney. The number of JG12-positive capillary endothelial cells was directly correlated with glomerular maturation grade and was inversely related with the tubular injury. Our findings suggest the imbalance between pro- and anti-angiogenic factors may be implicated in the loss of capillaries in associated with impaired nephrogenesis after angiotensin II blockade in the developing rat kidney.
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