Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Continuous flow reaction system for the synthesis of 2,2,2-trichloroacetophenone derivatives and its application
- Authors
- Ko, Byeng Ha; Yu, Subeen; Song, Kwang Ho; Lee, Sunwoo
- Issue Date
- 14-3월-2018
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Flow chemistry; Trichloroacetophenone; Decarboxylative chlorination; Propiolic acid; Trichloroisocyanuric acid
- Citation
- TETRAHEDRON LETTERS, v.59, no.11, pp.991 - 994
- Indexed
- SCIE
SCOPUS
- Journal Title
- TETRAHEDRON LETTERS
- Volume
- 59
- Number
- 11
- Start Page
- 991
- End Page
- 994
- ISSN
- 0040-4039
- Abstract
- A continuous flow reaction system was developed for the synthesis of 2,2,2-trichloroacetophenone derivatives. When aryl propiolic acids and water were mixed with trichloroisocyanuric acid in DMF at 5 degrees C, the 2,2,2-trichloroacetophenone derivatives were formed within 5 min with good yields. In addition, the resulting mixture was flowed to react with amines to give the corresponding benzamide. This flow reaction system provided higher yields within shorter times than the batch reaction system. (C) 2018 Elsevier Ltd. All rights reserved.
- Files in This Item
- There are no files associated with this item.
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.