Naringin Protects Pancreatic beta-Cells Against Oxidative Stress-Induced Apoptosis by Inhibiting Both Intrinsic and Extrinsic Pathways in Insulin-Deficient Diabetic Mice
DC Field | Value | Language |
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dc.contributor.author | Lim, Ye Jin | - |
dc.contributor.author | Kim, Jung Ho | - |
dc.contributor.author | Pan, Jeong Hoon | - |
dc.contributor.author | Kim, Jae Kyeom | - |
dc.contributor.author | Park, Tae-Sik | - |
dc.contributor.author | Kim, Young Jun | - |
dc.contributor.author | Lee, Jin Hyup | - |
dc.contributor.author | Kim, Jun Ho | - |
dc.date.accessioned | 2021-09-02T14:02:49Z | - |
dc.date.available | 2021-09-02T14:02:49Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-03 | - |
dc.identifier.issn | 1613-4125 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/76845 | - |
dc.description.abstract | Scope: Oxidative stress has been suggested to play a central role in the pathogenesis of diabetes, as well as other metabolic disorders. Naringin, a major flavanone glycoside in citrus species, has been shown to display strong antioxidant potential in in vitro and in vivo models of oxidative stress; however, the underlying protective mechanisms in diabetes are unclear. Methods and results: To study the protective effects and molecular mechanisms of naringin in preventing islet dysfunction and diabetes, we examined glucose homeostasis, beta-cell apoptosis, and inflammatory response in insulin-deficient diabetic mice exposed to acute oxidative stress with streptozotocin (STZ). Naringin dose-dependently ameliorated hyperglycemia and islet dysfunction in insulin-deficient diabetic mice. Naringin counteracted STZ-induced beta-cell apoptosis by inhibiting both the intrinsic (mitochondria-mediated) and extrinsic (death receptor-mediated) pathways. Furthermore, these protective effects were associated with suppression of DNA damage response and nuclear factor-kappa B-and mitogen-activated protein kinase-mediated signaling pathways, as well as reduction of reactive oxygen species accumulation and pro-inflammatory cytokine production in the pancreas. Conclusion: Taken together, our study provides insights into the underlying mechanisms through which naringin protects the pancreatic beta-cells against oxidative stress-induced apoptosis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | REACTIVE OXYGEN | - |
dc.subject | DNA-DAMAGE | - |
dc.subject | MECHANISMS | - |
dc.subject | GLUCOSE | - |
dc.subject | DEATH | - |
dc.subject | ERK | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | ACTIVATION | - |
dc.title | Naringin Protects Pancreatic beta-Cells Against Oxidative Stress-Induced Apoptosis by Inhibiting Both Intrinsic and Extrinsic Pathways in Insulin-Deficient Diabetic Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Young Jun | - |
dc.contributor.affiliatedAuthor | Lee, Jin Hyup | - |
dc.contributor.affiliatedAuthor | Kim, Jun Ho | - |
dc.identifier.doi | 10.1002/mnfr.201700810 | - |
dc.identifier.scopusid | 2-s2.0-85043324422 | - |
dc.identifier.wosid | 000426736500005 | - |
dc.identifier.bibliographicCitation | MOLECULAR NUTRITION & FOOD RESEARCH, v.62, no.5 | - |
dc.relation.isPartOf | MOLECULAR NUTRITION & FOOD RESEARCH | - |
dc.citation.title | MOLECULAR NUTRITION & FOOD RESEARCH | - |
dc.citation.volume | 62 | - |
dc.citation.number | 5 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | REACTIVE OXYGEN | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | ERK | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | diabetes | - |
dc.subject.keywordAuthor | naringin | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.subject.keywordAuthor | pancreatic beta-cells | - |
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