Low levels of 25-hydroxyvitamin D in children and adolescents with type 1 diabetes mellitus: a single center experience
- Authors
- Bae, Ki Nam; Nam, Hyo-Kyoung; Rhie, Young-Jun; Song, Dae Jin; Lee, Kee-Hyoung
- Issue Date
- 3월-2018
- Publisher
- KOREAN SOC PEDIATRIC ENDOCRINOLOGY
- Keywords
- Diabetes mellitus; Type 1; Vitamin D deficiency; Child; Case-control studies
- Citation
- ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, v.23, no.1, pp.21 - 27
- Indexed
- SCOPUS
KCI
- Journal Title
- ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
- Volume
- 23
- Number
- 1
- Start Page
- 21
- End Page
- 27
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/77232
- DOI
- 10.6065/apem.2018.23.1.21
- ISSN
- 2287-1012
- Abstract
- Purpose: Low vitamin D level is common in adults with diabetes mellitus (DM). We assessed vitamin D level and its associated factors in Korean youth with type 1 DM. Methods: Type 1 DM cases (n=85) and healthy controls (n=518) aged <20 years were included and grouped into 3 categories according to vitamin D level: deficiency (<20 ng/mL), insufficiency (20-30 ng/mL), or sufficiency (>= 30 ng/mL). Results: The mean serum vitamin D level was significantly lower (21.6 +/- 8.5 ng/mL vs. 28.0 +/- 12.0 ng/mL, P<0.001) and vitamin D deficiency prevalence was significantly higher (48% vs. 26%, P<0.001) in type 1 DM cases than in healthy controls. Logistic regression analysis revealed that type 1 DM cases were more likely to have vitamin D deficiency (P=0.004), independent of sex, age, and body mass index. Type 1 DM cases with vitamin D deficiency/insufficiency were mainly diagnosed in winter (November to April) (P=0.005), and the duration of diabetes was longer than in those with vitamin D sufficiency (P=0.046). However, season of diagnosis, duration of diabetes, prescribed daily insulin dose, and glycosylated hemoglobin and C-peptide levels were not associated with 25-hydroxyvitamin D (25(OH)D) level in type 1 DM cases after adjustment for other factors. Conclusion: We recommend assessment of serum 25(OH)D level in type 1 DM cases and to treatment if findings indicate insufficiency. Further studies investigating the mechanisms underlying vitamin D deficiency in youth with type 1 DM are needed.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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