7,10-Epoxyoctadeca-7,9-dienoic Acid: A Small Molecule Adjuvant That Potentiates beta-Lactam Antibiotics Against Multidrug-Resistant Staphylococcus aureus
DC Field | Value | Language |
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dc.contributor.author | Dasagrandhi, Chakradhar | - |
dc.contributor.author | Kim, Young-Soon | - |
dc.contributor.author | Kim, In-Hwan | - |
dc.contributor.author | Hou, Ching T. | - |
dc.contributor.author | Kim, Hak-Ryul | - |
dc.date.accessioned | 2021-09-02T22:28:01Z | - |
dc.date.available | 2021-09-02T22:28:01Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.issn | 0046-8991 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/81393 | - |
dc.description.abstract | The emergence of methicillin-resistant Staphylococcus aureus (MRSA) infections with multi-drug resistance needs effective and alternative control strategies. In this study we investigated the adjuvant effect of a novel furan fatty acid, 7,10-epoxyoctadeca-7,9-dienoic acid (7,10-EODA) against multidrug-resistant S. aureus (MDRSA) strain 01ST001 by disc diffusion, checker board and time kill assays. Further the membrane targeting action of 7,10-EODA was investigated by spectroscopic and confocal microscopic studies. 7,10-EODA exerted synergistic activity along with beta-lactam antibiotics against all clinical MRSA strains, with a mean fractional inhibitory concentration index below 0.5. In time-kill kinetic study, combination of 7,10-EODA with oxacillin, ampicillin, and penicillin resulted in 3.8-4.2 log(10) reduction in the viable counts of MDRSA 01ST001. Further, 7,10-EODA dose dependently altered the membrane integrity (p < 0.001) and increased the binding of fluorescent analog of penicillin, Bocillin-FL to the MDRSA cells. The membrane action of 7,10-EODA further facilitated the uptake of several other antibiotics in MDRSA. The results of the present study suggested that 7,10-EODA could be a novel antibiotic adjuvant, especially useful in repurposing beta-lactam antibiotics against multidrug-resistant MRSA. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | FURAN FATTY-ACID | - |
dc.subject | AMINOGLYCOSIDES | - |
dc.subject | MEMBRANE | - |
dc.title | 7,10-Epoxyoctadeca-7,9-dienoic Acid: A Small Molecule Adjuvant That Potentiates beta-Lactam Antibiotics Against Multidrug-Resistant Staphylococcus aureus | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Young-Soon | - |
dc.contributor.affiliatedAuthor | Kim, In-Hwan | - |
dc.identifier.doi | 10.1007/s12088-017-0680-2 | - |
dc.identifier.scopusid | 2-s2.0-85030862426 | - |
dc.identifier.wosid | 000414504200012 | - |
dc.identifier.bibliographicCitation | INDIAN JOURNAL OF MICROBIOLOGY, v.57, no.4, pp.461 - 469 | - |
dc.relation.isPartOf | INDIAN JOURNAL OF MICROBIOLOGY | - |
dc.citation.title | INDIAN JOURNAL OF MICROBIOLOGY | - |
dc.citation.volume | 57 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 461 | - |
dc.citation.endPage | 469 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | FURAN FATTY-ACID | - |
dc.subject.keywordPlus | AMINOGLYCOSIDES | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordAuthor | Furan fatty acids | - |
dc.subject.keywordAuthor | 7,10-Epoxyoctadeca-7,9-dienoic acid | - |
dc.subject.keywordAuthor | Synergistic antibacterial agent | - |
dc.subject.keywordAuthor | beta-Lactam antibiotics | - |
dc.subject.keywordAuthor | Multidrug-resistant Staphylococcus aureus | - |
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