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A BODIPY-based two-photon fluorescent probe validates tyrosinase activity in live cells
- Authors
- Bobba, Kondapa Naidu; Won, Miae; Shim, Inseob; Velusamy, Nithya; Yang, Zhigang; Qu, Junle; Kim, Jong Seung; Bhuniya, Sankarprasad
- Issue Date
- 18-10월-2017
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.53, no.81, pp.11213 - 11216
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 53
- Number
- 81
- Start Page
- 11213
- End Page
- 11216
- ISSN
- 1359-7345
- Abstract
- Herein, we report rational design, synthesis, and application of a two-photon fluorescent probe (Tyro-1) for tracking intracellular tyrosinase activity. The chemoselective detection of tyrosinase is precluded from interference of other competitive omnipresent oxidizing entities in cellular milieu. The probe showed 12.5-fold fluorescence enhancement at lambda(em) = 450 nm in the presence of tyrosinase. The nontoxic probe Tyro-1 provides information about H2O2-mediated upregulation of tyrosinase through cellular imaging. Its two-photon imaging ability makes it a noninvasive tool for validating the expression of tyrosinase in the live cells.
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