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Synthesis and biological evaluation of peptide-derived TSLP inhibitors
- Authors
- Park, Seonghu; Park, Yeeun; Son, Sang-Hyun; Lee, Kiho; Jung, Yong Woo; Lee, Ki Yong; Jeon, Young Ho; Byun, Youngjoo
- Issue Date
- 15-Oct-2017
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Allergic disease; TSLP inhibitors; Peptides; TSLP receptors
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.27, no.20, pp.4710 - 4713
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 27
- Number
- 20
- Start Page
- 4710
- End Page
- 4713
- ISSN
- 0960-894X
- Abstract
- Thymic stromal lymphopoietin (TSLP) is a type II cytokine which is associated with most inflammatory allergic disorders in humans. It is produced mainly by epithelial cells with important role in the development of chronic inflammatory diseases by activating T-helper cell type-2 (T(H)2) pathways. In this study, a total of 16 peptides were prepared by solid phase peptide synthesis based on amino acid sequences of the interface between TSLP and TSLP receptor. Their TSLP inhibition activities were determined by ELISA assay. Among them, three peptides (6-8) exhibited >50% inhibition at concentration of 0.3 mM. They can be used as hit compounds for developing peptide-based TSLP inhibitors. (C) 2017 Elsevier Ltd. All rights reserved.
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Related Researcher
- JEON, Young Ho
- College of Pharmacy (Department of Pharmaceutical Science)