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Fate of Neutrophils during the Recovery Phase of Ischemia/Reperfusion Induced Acute Kidney Injury

Authors
Cho, WonyongSong, Jie-YoungOh, Se WonKim, Myung GyuKo, Yoon SookLee, Hee YongJo, Sang Kyung
Issue Date
10월-2017
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
Ischemia/Reperfusion; Neutrophil; Apoptosis; Reverse Transendothelial Migration; Recovery
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.32, no.10, pp.1616 - 1625
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
32
Number
10
Start Page
1616
End Page
1625
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/82154
DOI
10.3346/jkms.2017.32.10.1616
ISSN
1011-8934
Abstract
Effective clearance of inflammatory cells is required for resolution of inflammation. Here, we show in vivo evidence that apoptosis and reverse transendothelial migration (rTEM) are important mechanisms in eliminating neutrophils and facilitating recovery following ischemia/reperfusion injury (IRI) of the kidney. The clearance of neutrophils was delayed in the Bax knockout (KO)(BM) -> wild-type (WT) chimera in which bone marrow derived cells are partially resistant to apoptosis, compared to WTBM -> WT mice. These mice also showed delayed functional, histological recovery, increased tissue cytokines, and accelerated fibrosis. The circulating intercellular adhesion molecule-1 (ICAM-1)(+) Gr-1(+) neutrophils displaying rTEM phenotype increased during the recovery phase and blockade of junctional adhesion molecule-C (JAM-C), a negative regulator of rTEM, resulted in an increase in circulating ICAM-1(+) neutrophils, faster resolution of inflammation and recovery. The presence of Tamm-Horsfall protein (THP) in circulating ICAM-1(+) neutrophils could suggest that they are derived from injured kidneys. In conclusion, we suggest that apoptosis and rTEM are critically involved in the clearance mechanisms of neutrophils during the recovery phase of IRI.
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