Low-Dose Bisphenol A Increases Bile Duct Proliferation in Juvenile Rats: A Possible Evidence for Risk of Liver Cancer in the Exposed Population?
- Authors
- Jeong, Ji Seong; Nam, Ki Taek; Lee, Buhyun; Pamungkas, Aryo Dimas; Song, Daeun; Kim, Minjeong; Yu, Wook-Joon; Lee, Jinsoo; Jee, Sunha; Park, Youngja H.; Lim, Kyung-Min
- Issue Date
- 1-9월-2017
- Publisher
- KOREAN SOC APPLIED PHARMACOLOGY
- Keywords
- Bisphenol A; Toxicokinetics; Bile duct proliferation; Juvenile animals
- Citation
- BIOMOLECULES & THERAPEUTICS, v.25, no.5, pp.545 - 552
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BIOMOLECULES & THERAPEUTICS
- Volume
- 25
- Number
- 5
- Start Page
- 545
- End Page
- 552
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/82289
- DOI
- 10.4062/biomolther.2017.148
- ISSN
- 1976-9148
- Abstract
- Increasing concern is being given to the association between risk of cancer and exposure to low-dose bisphenol A (BPA), especially in young-aged population. In this study, we investigated the effects of repeated oral treatment of low to high dose BPA in juvenile Sprague-Dawley rats. Exposing juvenile rats to BPA (0, 0.5, 5, 50, and 250 mg/kg oral gavage) from post-natal day 9 for 90 days resulted in higher food intakes and increased body weights in biphasic dose-effect relationship. Male mammary glands were atrophied at high dose, which coincided with sexual pre-maturation of females. Notably, proliferative changes with altered cell foci and focal inflammation were observed around bile ducts in the liver of all BPA-dosed groups in males, which achieved statistical significance from 0.5 mg/kg (ANOVA, Dunnett's test, p<0.05). Toxicokinetic analysis revealed that systemic exposure to BPA was greater at early age (e.g., 210-fold in C-max, and 26-fold in AUC at 50 mg/kg in male on day 1 over day 90) and in females (e.g., 4-fold in C-max and 1.6-fold in AUC at 50 mg/kg vs. male on day 1), which might have stemmed from either age- or gender-dependent differences in metabolic capacity. These results may serve as evidence for the association between risk of cancer and exposure to low-dose BPA, especially in young children, as well as for varying toxicity of xenobiotics in different age and gender groups.
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Collections - College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
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