Anti-Inflammatory Effects of Stearidonic Acid Mediated by Suppression of NF-kappa B and MAP-Kinase Pathways in Macrophages
- Authors
- Sung, Jeehye; Jeon, Heemang; Kim, In-Hwan; Jeong, Heon Sang; Lee, Junsoo
- Issue Date
- 9월-2017
- Publisher
- WILEY
- Keywords
- Stearidonic acid; Echium oil; Anti-inflammatory; NF kappa B (nuclear factor kappa B); MAPK (mitogen-activated protein kinases) pathway
- Citation
- LIPIDS, v.52, no.9, pp.781 - 787
- Indexed
- SCIE
SCOPUS
- Journal Title
- LIPIDS
- Volume
- 52
- Number
- 9
- Start Page
- 781
- End Page
- 787
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/82317
- DOI
- 10.1007/s11745-017-4278-6
- ISSN
- 0024-4201
- Abstract
- Stearidonic acid (SDA, 18:4n-3) is an omega-3 polyunsaturated fatty acid present in oils derived from plants of the Boraginaceae family. In this study, we determined the anti-inflammatory effects of SDA isolated from echium oil on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. SDA significantly downregulated the levels of the inducible nitric oxide synthase (iNOS) protein, thereby suppressing the production of nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. In addition, SDA inhibited the nuclear translocation and promoter activity of nuclear factor kappa B (NF kappa B) and the phosphorylation of mitogen-activated protein kinases (MAPK) such as extracellular signal regulated kinase 1/2, c-jun N terminal kinase, and p38 in LPS-stimulated RAW 264.7 cells. Our results showed that SDA exerted anti-inflammatory effects by suppressing iNOS-mediated NO production via inactivation of NF kappa B and MAPK signaling pathways.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.