Prospective Evaluation of the Clinical Implications of the Tumor Metabolism and Chemotherapy-Related Changes in Advanced Biliary Tract Cancer
- Authors
- 권현우; Kwon, Hyun Woo
- Issue Date
- 8월-2017
- Publisher
- SOC NUCLEAR MEDICINE INC
- Keywords
- biliary tract neoplasm; carcinoma; positron-emission tomography; metabolism; prognosis
- Citation
- JOURNAL OF NUCLEAR MEDICINE, v.58, no.8, pp.1255 - 1261
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NUCLEAR MEDICINE
- Volume
- 58
- Number
- 8
- Start Page
- 1255
- End Page
- 1261
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/82596
- ISSN
- 0161-5505
- Abstract
- Tumor metabolism measured by F-18-FDG PET has a diagnostic and prognostic role in several cancers. The clinical implication of tumor metabolism in biliary tract cancer (BTC) has not been studied well. Therefore, we evaluated the prognostic value of tumor metabolism and chemotherapy-related changes in advanced BTC patients. Methods: We prospectively enrolled advanced BTC patients before the initiation of palliative chemotherapy. Using F-18-FDG PET, we assessed the baseline SUVmax and monitored the changes in SUVmax during chemotherapy. We analyzed the associations between SUVmax, and clinicopathologic factors and clinical outcomes. Results: Seventy-five patients were enrolled. All patients received gemcitabine/ cisplatin as first-line chemotherapy. Primary tumor site, histologic differentiation, molecular characteristics, laboratory findings, and disease extent were associated with the metabolic characteristics. The high-metabolism group showed worse survival outcome (hazard ratio [HR] = 4.09, P = 0.001 for progression-free survival; HR = 2.61, P = 0.019 for overall survival [OS]) than the low-metabolism group. The lesser reduction of SUVmax was also associated with worse outcome (HR = 3.35, P = 0.002 for progression-free survival; HR = 1.96, P = 0.082 for OS). When both baseline
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