Diagnostic accuracy of anti-Sa and anti-RA33 antibodies in rheumatoid arthritis: a meta-analysis

Abstract

Objective. This study evaluated the diagnostic accuracy of anti-Sa and anti-RA33 antibodies in rheumatoid arthritis (RA). Methods. PubMed, Embase, and Cochrane library databases were searched for relevant studies, and 2 meta-analyseswere performed to determine the diagnostic accuracy of anti-Sa and anti-RA33 antibodies in patients with RA. Results. The meta-analysis included 17 studies. Pooled sensitivity and specificity of anti-Sa antibody were 39.5% (95% confidence interval [CI] 36.5-42.4) and 96.8% (95 % CI 95.9-97.4), respectively, and those of anti-RA33 antibody were 31.8% (95 % CI 28.7-35.0) and 90.1% (95 % CI 87.8-92.1), respectively. PLR, NLR, and DOR of anti-Sa antibody were 14.11 (95% CI 7.076-28.13), 0.607 (95% CI 0.558-0.703), and 22.76 (95% C, 11.10-46.69), respectively, and those of anti-RA33 antibody were 3.429 (95% CI 2.039-5.765), 0.761 (95% CI 0.681-0.851), and 4.597 (95 % CI 2.602-8.121), respectively. AUC and Q* index for anti-Sa antibody were 0.558 and 0.543, respectively, while those for anti-RA33 antibody were 0.501 and 0.500, respectively. Conclusions. Our meta-analysis indicated that both anti-Sa and anti-RA33 antibodies were highly specific but not sensitive for diagnosing RA.