Protective effects of chebulic acid on alveolar epithelial damage induced by urban particulate matter
DC Field | Value | Language |
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dc.contributor.author | Lee, Kyung-Won | - |
dc.contributor.author | Nam, Mi-Hyun | - |
dc.contributor.author | Lee, Hee-Ra | - |
dc.contributor.author | Hong, Chung-Oui | - |
dc.contributor.author | Lee, Kwang-Won | - |
dc.date.accessioned | 2021-09-03T03:50:35Z | - |
dc.date.available | 2021-09-03T03:50:35Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-07-19 | - |
dc.identifier.issn | 1472-6882 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/82812 | - |
dc.description.abstract | Background: Chebulic acid (CA) isolated from T. chebula, which has been reported for treating asthma, as a potent anti-oxidant resources. Exposure to ambient urban particulate matter (UPM) considered as a risk for cardiopulmonary vascular dysfunction. To investigate the protective effect of CA against UPM-mediated collapse of the pulmonary alveolar epithelial (PAE) cell (NCI-H441), barrier integrity parameters, and their elements were evaluated in PAE. Methods: CA was acquired from the laboratory previous reports. UPM was obtained from the National Institutes of Standards and Technology, and these were collected in St. Louis, MO, over a 24-month period and used as a standard reference. To confirm the protection of PAE barrier integrity, paracellular permeability and the junctional molecules were estimated with determination of transepithelial electrical resistance, Western Blotting, RT-PCR, and fluorescent staining. Results: UPM aggravated the generation of reactive oxygen species (ROS) in PAE and also decreased mRNA and protein levels of junction molecules and barrier integrity in NCI-H441. However, CA repressed the ROS in PAE, also improved barrier integrity by protecting the junctional parameters in NCI-H411. Conclusions: These data showed that CA resulted in decreased UPM-induced ROS formation, and the protected the integrity of the tight junctions against UPM exposure to PAE barrier. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.subject | STRESS-INDUCED DISRUPTION | - |
dc.subject | TIGHT JUNCTIONS | - |
dc.subject | AIR-POLLUTION | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | LUNG INJURY | - |
dc.subject | MOLECULAR-BASIS | - |
dc.subject | IN-VITRO | - |
dc.subject | PARTICLES | - |
dc.subject | EXPOSURE | - |
dc.subject | BARRIER | - |
dc.title | Protective effects of chebulic acid on alveolar epithelial damage induced by urban particulate matter | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kwang-Won | - |
dc.identifier.doi | 10.1186/s12906-017-1870-5 | - |
dc.identifier.scopusid | 2-s2.0-85025067617 | - |
dc.identifier.wosid | 000405789400001 | - |
dc.identifier.bibliographicCitation | BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, v.17 | - |
dc.relation.isPartOf | BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.citation.title | BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.citation.volume | 17 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.subject.keywordPlus | STRESS-INDUCED DISRUPTION | - |
dc.subject.keywordPlus | TIGHT JUNCTIONS | - |
dc.subject.keywordPlus | AIR-POLLUTION | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | LUNG INJURY | - |
dc.subject.keywordPlus | MOLECULAR-BASIS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | PARTICLES | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.subject.keywordPlus | BARRIER | - |
dc.subject.keywordAuthor | Urban particulate matter | - |
dc.subject.keywordAuthor | Chebulic acid | - |
dc.subject.keywordAuthor | Pulmonary alveolus | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Alveolar barrier dysfunction | - |
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