Effect of Valerian/Hop Mixture on Sleep-Related Behaviors in Drosophila melanogaster
DC Field | Value | Language |
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dc.contributor.author | Choi, Hyeon-Son | - |
dc.contributor.author | Ko, Bong Soo | - |
dc.contributor.author | Kim, Hae Dun | - |
dc.contributor.author | Hong, Ki-Bae | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.date.accessioned | 2021-09-03T04:25:42Z | - |
dc.date.available | 2021-09-03T04:25:42Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/82944 | - |
dc.description.abstract | The aim of this study was to investigate the sleep-promoting effect of a Valerian/Hops mixture in fruit flies. The HPLC analysis showed that Valerenic acid (1260.53 mu g/g of extract) and Xanthohumol (Cascade: 827.49 mu g/g, Hallertau: 763.60 mu g/g, Saaz: 186.93 mu g/g) were contained in Valerian and Hop, respectively. The sleep patterns of fruit flies on the Valerian/Hops were examined in both baseline and caffeine-treated conditions. Total activities of flies significantly decreased in 20 mg/mL Valerian (74%), 10 mg/mL Cascade (25%), and 5 mg/mL Hallertau (11%) during nighttime or daytime compared with the control. Valerian/Cascade mixture showed longer sleeping time (ca. 20%) than control group. This mixture-mediated effect was partly observed in caffeine-treated flies. Valerian/Cascade mixture upregulated mRNA expressions of gamma-aminobutyric acid (GABA) receptors and serotonin receptor, and GABA receptors were more strongly regulated than serotonin receptor. In competitive GABA receptor binding assay, Valerian/Cascade mixture extract showed a higher binding ability on GABA receptor than Valerenic acid or/and Xanthohumol which are estimated to be active compounds in the extract. This study demonstrates that a Valerian/Cascade mixture extract improves sleep-related behaviors, including sleeping time, by modulating GABAergic/serotonergic signaling. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC JAPAN | - |
dc.subject | HUMULUS-LUPULUS | - |
dc.subject | VALERENIC ACID | - |
dc.subject | EXTRACT | - |
dc.subject | RECEPTORS | - |
dc.subject | BINDING | - |
dc.subject | HOPS | - |
dc.subject | GABA(A) | - |
dc.subject | XANTHOHUMOL | - |
dc.subject | SEROTONIN | - |
dc.subject | MEDICINE | - |
dc.title | Effect of Valerian/Hop Mixture on Sleep-Related Behaviors in Drosophila melanogaster | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.1248/bpb.b17-00262 | - |
dc.identifier.scopusid | 2-s2.0-85021682586 | - |
dc.identifier.wosid | 000404670100020 | - |
dc.identifier.bibliographicCitation | BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.40, no.7, pp.1101 - 1110 | - |
dc.relation.isPartOf | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.title | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.volume | 40 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1101 | - |
dc.citation.endPage | 1110 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | HUMULUS-LUPULUS | - |
dc.subject.keywordPlus | VALERENIC ACID | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | HOPS | - |
dc.subject.keywordPlus | GABA(A) | - |
dc.subject.keywordPlus | XANTHOHUMOL | - |
dc.subject.keywordPlus | SEROTONIN | - |
dc.subject.keywordPlus | MEDICINE | - |
dc.subject.keywordAuthor | insomnia | - |
dc.subject.keywordAuthor | sleep-promotion | - |
dc.subject.keywordAuthor | Valerian | - |
dc.subject.keywordAuthor | Hop | - |
dc.subject.keywordAuthor | Drosophila melanogaster | - |
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